Pakistan spinner Sajid Khan struck four times to leave the West Indies in deep trouble on 54-5 at lunch on the third day of the first Test in their chase of 251 for victory.
The West Indies need 197 runs to win while Pakistan are chasing five wickets in a battle between the two basement sides in the World Test Championship.
On a Multan Stadium pitch that has a sharp turn, the West Indies lost skipper Kraigg Brathwaite (12), Keacy Carty (six), Kavem Hodge (nought) and Mikyle Louis (13) — all to Sajid, who has figures of 4-25.
In the last over before the lunch break, fellow spinner Noman Ali trapped Justin Greaves leg before for nine to give Pakistan a sniff of victory.
Alick Athanaze was unbeaten on 12.
Earlier, Jomel Warrican finished with 7-32 in 18 spin-tricky overs to bundle Pakistan out for 157 after they resumed on 109-3, managing to add just 48 runs.
Warrican tore through the Pakistan batting line-up with nagging line and length to claim match figures of 10-101, his first 10-wicket haul.
His previous best innings figures of 4-50 came against Sri Lanka at Galle in 2021.
He also improved on the previous best figures by a West Indian in Pakistan, held by fast bowler Malcolm Marshall with 5-33 at Lahore in 1986.
Warrican dismissed overnight batter Saud Shakeel with the first ball of the day for two and then had Mohammad Rizwan in his next over for the same score.
He continued the demolition act with the wickets of Kamran Ghulam (27), Noman (nine) and Sajid (five).
Fellow spinner Gudakesh Motie ended the innings by dismissing Salman Agha for 14.
The second match starts from January 25, also in Multan.
